1.) pretuned for Euro IS300 then.
2.) As you can see in the is300.net discussion, the most gains were made by changing the timing. That can only be made with the E-Manage. Not the S-AFC II.
3.) Buy a E-manage clone cable (~50 US$) and download the E-Manage software. Then you get for a total of ~450US$ a really good base for tuning. You then need some time on a dyno with a wideband and a knocksensor and you get all out for your N/A mods.
As you can see they made gain of almost 20 hp at some parts (peak=10hp). So isnt that worth the money?
If you already spend money on headers, racepipe, exhaust and stuff like that, this is maybe what you should get.