My experience of wonder wheels (and similar acid-based products) is that it is fine as long as the surface of the wheel is undamaged. If there is damage to the laquer, it seems to get behind it and make it worse. To be honest, because of the design of the wheels, I just use a sponge and water and do it a bit more often than I used to, before the kak bakes itself on. I'm worried about the acid damaging them, given the obvious problems they already tend to suffer - ie corrosion.
Talking of damage, I've had my IS200 for 5 months now, my wife scuffed the front wheel after a week. She took it to one of these places that do little repairs, I wasn't that impressed with the result. It was academic really, though, because the very next day she scuffed it again, in exactly the same place. She then did it again four more times over the next few months, the last of which scuffed the wheel right the way round.
She's been scuff-free for a few months now, so I've banged the spare wheel on. Methinks it won't survive for that long, but hey-ho. From what everyone else has said, the wheels will probably corrode soon anyhoo. I think they were refurbed before I bought the car, cos they were immaculate, but I can already see a few spots that I'm keeping an eyeball on.