I bought an '07 GS450-h SE-L, 25k miles with wood pack, about 6 months ago, from Lexus Coventry. It's in metallic Mesa Red with the light colour leather and looks absolutely superb when the sun catches it. I paid 31k but consider that fair because the car was in a superb almost new condition - it even still smelt new. For me two major plus points of the car are the adaptive cruise control (this is stunningly good) and the acceleration (when you put your foot down and you get both motors kicking in it feels like a rocket lift off). I took it down the Fosse Way a few weeks ago, a road notorious for lack of places to pass, and found that I could easily just zip past other cars that in any other car I would never have even dared to attempt.
It's a very different car to any I have driven before, and I agree with the earlier comments about reduced headroom and small boot, but all in all I'm a happy bunny (and even better - my wife loves it also !)
BTW Lexus Coventry offer superb service.