Hotwheels - I'd say go for it. I've had my 220d for a year now and I'm delighted with it. Yes, it takes a while to get used to the required driving style, but after a bit of practice (and not driving it like an old lady) I consistently get around 50 mpg and it's got a good turn of speed when you need it. Admittedly most of my driving is on motorways. 6th gear seems usable to me at 70 mph as long as it's not a steep incline.
The quality of the Lexus servicing is a bit variable - I've not had a great experience with them to be honest (mainly Leicester, but other dealers may be better).
There does seem to be a considerable amount of negative opinion on these forums regarding the 220d, but I can only speak for my car, which is superb. Mine has the built in sat-nav and Mark Levinson stereo system, which if you get the choice, I'd highly recommend paying a bit more for.
Good luck with your purchase.