I bought my 2007 LS460 in August 2019, I px'd my 1995 LS400 (120,000 miles) for it. The 400 had rust problems in rear wheel arch area, in spite of my Waxoyl applications and occasional speedo/rev counter not working. I'd had the car 8 years and considered it a superb car.
Now the 460 is in a quite different class, good performance, much better brakes than the 400, but that was from a different era. No cam belt changes on the 460 so one less worry. Looks are subjective but I think the 460 has attained a real identity of it's own, largely unchanged to date, I don't really like the ugly front on the latest version. The 430 looked too much like a Merc 'S'.
Not without it's problems though, MOT last year required upper suspension arms. This year MOT (this week) requires more bush changes and one suspension bag renewal. The horn stopped working recently, after doing some research it seems likely the fault is in the steering wheel - we'll see on that. The VSC warning light comes on occasionally and then goes off or I reset it. Haven't got to bottom of that yet, probably sensor. Changed the front passenger seat belt stalk last year as became faulty and after just buying the car had to renew 2 of the tyre pressure indicators (expensive) as the batteries had run out, tried to renew batteries but not possible.
I'm a great believer in good induction, bought a set of NGK Iridium spark plugs (£307) and sport air filter.