I looked into this a while back & came away with the conclusion that it wasn't as easy as it sounds & probably problematic on a Hybrid. The reason is simple, each time the engine starts it has to run on petorl first & then switch to LPG. As you know, even on long runs down the motorway, the engine switches on & off as required & most of the time you aren't even aware of it, so unless you have an automatic system to work with the Hybrid controls you may well run into problems. Personally I'd seek the advice of Lexus technicians before you spend £1800, because the Hybrid parts of a 56 plate will still be under warranty & engine rebuilds are VERY expensive, probably more than the LPG conversion due to high labour rates.
All that said if you have a wonder-system that does work let us know, for some, as you observe, the cost (& loss of the spare wheel?) may well be worth considering.