I'm no expert on this, but I reckon that this won't be "plug and play". The Sat Nav screen also controls the climate control. Because of the size of the unit you woudl have to remove the stereo and climate control panel. There is also the CD/DVD unit in the boot with associated wiring.
If you do manage to get a second hand unit, make sure it's all working properly as replacement touch screen unit is £3500 from Lexus, or £1700 for a reconditioned one. The CD/DVD unit in the boot is about £2000 to replace if faulty.
Cheers,
Sandeep