Hi!
I'm also having the same "problem". Just bought my 2014 Is300h a month ago. Not before recently I've notived noise from the car mainly around 50-60 km/h and espescially when slightly accelerating or decelerating. The noice is not depending on the rpm, but the speed of the car. I got the dealer to put on brand new michelin tires before I got it, and as far as I can see they are from 2016, so I dont think that bad tire quality is the reason. Just like you, I think it sounds more like the noise you have when a bearing has failed, but its the same either in corners or driving straight ahead, so the bearings should be ok. I might have a technician to look at it for me. I'll let you know the result if they find anything wrong, but I'm afraid thats just how the car should be.
Sorry for my "noobie" english, I'm not english 😀