I have an IS 200se Auto, choice was mainly due to the fact that I do a lot of motorway miles and inner city driving so, as someone has already quoted, I became lazy, however it is easy driving.
I mean, I get on the motorway, set the cruise control to 70 (not that I ever exceed the limit!!! ) and kick off my shoes and get in the back, lie down, close my eyes, have a kip and then arrive safe and sound!!!!
Seriously, the cruise control came as standard on the se auto, I also have a mate that bought the manual and said it was a pain in the arse when you accelerate out of a junction and then have to change halfway out due to the 6 speed box!
Its a personal choice in the end. I got the auto cos it can be an old mans auto or you can hit the PWR button and keep the revs longer for some fun! albeit not as quick as the manuals or as good mpg, the decision... is yours!!!
Hope that helps
Billy