Definetely another Lexus, not the new IS, becouse there is not possibility to get the 350 in Euope by now, so I'll go for the RX 350 or 400, or maybe for the GS 300, although I can't understand why it did not still use the 3500 cc version (272 or better the 300 hp version).
I am not going for generalistics brands. Don't do it, you will remember Lexus.