Had one for a few days on demo, fair amount of motorway driving at around 75mph (indicated, officer...) with some heavy traffic and some town work. When I handed it back, it was showing 51mpg average. That car had done 4000 miles so was maybe run in a bit better than brand new models.
This compared very favourably with the 320d ED as in traffic the stop/start system was useless, whereas the Lexus hybrid system was in its element!
A few folks, me included, appear to have been able to use the low BIK to our favour to het the IS.... much better than a 3 Series etc as i've still only seen a handful of IS's on the road since they came out!