We had this on our IS too. Took it back to Lexus as it was still under warranty, they had to take it out and send to Japan to get it fixed. Was a bit of a shame to drive around with a huge hole in the centre console til we got it back though!
Mum had a similar problem with hers too but hers wasn't bought from Lexus so she is just living without the cd now cause the rest of it still works.