best bet may be take it to a dealer and ask them to try one, on the pretence you going to buy a disc off them. I see no real reason why it shouldn't as the disc contains all the software as well as maps, but you never know. With most sat nav's, even fitted ones you buy a disk for the country you are travelling to, so therefore you should in theory be able to buy a disk from anywhere and it should work, but there is the danger it has to be sourced from the originating country. Therefore if it doesn't work, contact a Lexus delaer in USA for a European disk.