Buy one, buy one now!
I bought an '07 250 auto 2 months ago and I'm truly truly impressed. It's the SE-L with Mark Levison hardware and multimedia pack... It's the dogs danglies!
The auto box is pretty damn smooth and mpg as mentioned is in the early 30's if you're not thrashing it.
It's a pretty heavy motor, just over 2 ton... And it feels very solid.
I honestly thought the sat nav and reverse camera were just an added bonus, however I use both every day without fail and am SO glad I grabbed the SE-L when I did.
The SE-L also has the Xenon lights along with other upgrades so well worth it... And will make it easier to sell on I would guess.
Oh, mine has 92k on the clock with full lexus history and it drives like it's been sat in a showroom since new... It really does feel that good! Just to note, my last couple of cars have been a Mercedes C class and Jaguar x-type... Neither felt as good to drive or own....
So.. As I said... Go buy one! ;-)