Yes, I had various quotes for a new key for my rx400h from local key places and they varied a lot in the region of £20 to £50. In the end, I tried a professional locksmith who did it much cheaper- under £10, I believe. He even had a suitable blank in stock, although it was badged Toyota instead of Lexus, and the shank was a little longer than necessary. The label has the following markings:
CMII ID: 2005DJ1379
Model: 12BBY-08
Denso
Aside from the Toyota badge and the slightly elongated shank, it looks identical to the original Lexus unit, and the electronics transferred easily. There was no coding of the key needed.
Hth.