It seems as though some IS's suffer from a variety of noises whilst for some strange reason others don't, annoyingly there is no hard and fast rule as to the cause(s). Lexus told me that some IS's had a knocking from the suspension struts which even though they replaced them the noise remained.
After having both Lexus and my mate who runs his own garage, look at the car, it's clear that suspension bushes, ball joints etc don't seem to be the cause, my first port of call will be brake caliper slide pins changed and brake pads greased. The discs are fairly new and the pads are fine, will see where I go from there.
I'm almost in the same position as you Ashar as it seems to come down to how much we are willing to throw at the problem.
Really annoying as it spoils an otherwise perfect drive.