Go for the Honda, the boot in the sportcross is not so big and the mpg will grind on you.
Plus, although the quality and ownership of the Lexus will be 100%, the rear wheel drive is nice, but you will probably hate the clutch/drive take up action you will get after a while (unless auto - were these only auto?) in which case the 4sd auto is rubbish compared with the IS250 auto box! Its a bit basic! :-)
And with a kid on the way, you will need all the space and practicality you can get, which is not really the Lex! And the rear leg room is rubbish, and for car seats, its a nightmare to get one thats fits correctly - though you will have Isofix on that model I think.