Powertrain-wise, my IS200 has been running like clockwork (touches wood). She's travelled 114,000 miles so far.
Apart from that, I had the following issues:
Front lower ball joints were shot at 86,000 miles
Front shock absorbers were also leaking at 86,000 miles
Rear left shock has started to weep oil, and will probably need replacing during the next oil change
I think that's pretty much it, apart from consumables like brake pads, tyres, etc