peniole

New policies now include ADAS re-calibration in their text. I would insist on an OEM lexus screen. I'd be watching the replacement to make sure they don't screw up the surrounds. Not specific to the ES, but you read so many bad experiences where a screen replacement results in a water leak. Yes the screen is acoustic. It's also structurally important. I would try to avoid driving to allow maximum cure time. That being said, If it can be repaired, I'd go for it. If it's a short crack, a drill at the impact point and filling with that liquid glass material that hardens on UV treatment would be invisible. I've had that done on a past car and you could hardly see the crack anymore, and it held till we sold the car. Good luck. I'm just as persnickety. I feel your pain.

It thinks you aren't holding the wheel.

To start with: - Fix the stupidity of privatization of public utilities. Nationalization (although happening in France) seems to be a dirty word. So next best thing is cap the percent of profits private companies can squeeze out of public utilities. Furthermore, a set percentage of those profits are mandated to be put back into infrastructure development and R&D. - De-couple gas prices from electricity generation. Only 40% of UK electricity is made from gas. Why the hell should its price be held ransom to the price of gas? - Taxation of motorists is used for motoring related infrastructure. You want money for other projects raise it from another source of revenue. This muddying of the public purse "oh let's put it in one pot, the plebs won't notice what we're doing" has to stop. - Ban companies lobbying politicians. Ban all gifts to politicians. - MPs can buy their own damn lunch. I can't believe the amount of food waste reported for Westminster, 2.6 million meals binned (although they don't state the period over which that happened). - MPs can no longer vote on their own salary rises. That is a no brainer right there. That's off the top of my head.

^^ Yup, watch those corners. Can cause some real damage. ^^

I received a link last time. No video. I've seen reports on here, seems I'm not the only one.

Yup, I don't let them wash mine either 😁 For that matter I don't let them adjust tire pressures as well. They're too warm by the time you arrive, no way will they be able to get it right. So I check it myself the morning of to cut them off at the pass.

The curver one I posted up there can take 150kg if I remember correctly. I'm not too light either.

I you prefer something lighter, this one worked well too https://www.amazon.co.uk/Rubbermaid-Commercial-Products-R034721-Stepstool/dp/B003N9CMPQ

I used one similar to the top 3 results on this page when I had my F150 https://www.diy.com/departments/tools-equipment/ladders-steps/work-platforms/DIY637211.cat

https://www.ft.com/content/92323f6f-1b25-4cf2-a73f-6b9c0cf12f82 “Customers faced with high bills are paying too much because the government failed to reform the market,..In terms of solutions,... the price of electricity should be tied to the cost of production, rather than always to the marginal cost of gas, which had enabled many renewable producers to make “supernormal profits” linked to the higher price of gas while their own costs “haven’t changed one iota”.

^^+1 on megs quick interior detailer. No shine.

Given that only 40% of our electricity in the UK is generated by gas, the price per kWh electricity should not have gone up this much. The reason it has is a stupid agreement between the uk govt. and the renewable generator companies that allow them to charge fixed market prices (which are set by gas) through to 2037. So they are making out like bandits. Kwasai Karteng is currently in negotiations with them to break this ridiculous deal.

Best place as any to post this energy thought exercise especially as we're expecting 52p per kWh electricity soon. Ive been looking at solar panels options for our new build, and ran into the absurd new SEG tariffs that replace FiT. Now FiT was never going to last, it was mostly to get the solar industry going, but the new SEG scheme is laughable: You can be paid anywhere from 1.5 to currently a maximum of 12p per kWh you export to the grid. Keep in mind we're averaging 28p per kWh used (without taxes, levies,...etc.). If that imbalance wasn't enough, your import and export tabs are kept separate. So even if you generate all your electricity consumption for the day, just at the wrong time, you'll still be paying for electricity at the ridiculously inflated rates. Let me give you an example: You're out and about for an hour, it's sunny and you're gathering whatever you need for you upcoming DIY, car maintenance...etc. project. Meanwhile your system has produced 3kWh, your home used about 0.5kWh, and it exported 2.5kWh at 5p/kWh (current SEG average). Now you're back, you get out your power tools and you're using more power than your system can generate. Let's say you use 5.5kWh to zero out the maths. 3kWh from the solar system, and 2.5kWh back from the grid. You're now paying for that 2.5kWh at 28p/kWh even though you generated an equivalent amount an hour ago and were paid 5p/kWh. Now there has to be some monetary charge for that storage and flexibility admittedly, but do you think that is worth 23p/kWh and soon more? Only way around it is to have battery storage/tesla powerwall. Even with those the best SEG tariff will currently pay 12p/kWh for excess you can't store. That's still a ridiculous spread. Thoughts.

Love how he points out the common lets service your AC scam @28mins. If it aint broke, no matter how old the car, don't fix it!

Sadly, not unique to the ES, or toyota for that matter. I suspected an evaporator leak in my 10th gen honda civic, and the teardown is remarkably similar! The whole dash comes out, the steering column and even the structural cross brace same as here. The only difference was the blower box/ filter was separate rather than part of the same unit. See (mute, don't know the language but it isn't English):

It was, since the 90's.

Yes, I actually already said that earlier in the thread. PSA is no longer an approved NHS screening test, scroll up/page1.

I agree with everything else in your post but this quote. Yes, a biopsy is the gold standard for diagnosing every single cancer, no exceptions. But how do you decide who to biopsy? You can't biopsy the whole population. A biopsy is not a screening test. It is too invasive.

Not as simple as recommending one procedure over another, center expertise plays a big role in the outcome. Cyberknife is plainly radiation therapy, that's been around for eons, but the cyberknife takes out surgeon/user skill and replaces it with a robot that does the monitoring and moves the radiation in response to what you, the patient, are doing. In the end it's still a rather blunt instrument. Any cell exposed to radiation dies, which is why the robotic precision is so important. How many times did they tell you to hold still? I prefer molecularly targeted therapies. That's is where we figure out why/how the cancer happened, and specifically shut down that pathway. Unfortunately, we haven't figured out each and every pathway in every cancer. Some prostate cancer patients for example may have a BRCA mutation. That's a gene that is responsible for fixing DNA breaks. Also known to be mutated in breast cancer. We have a therapy that specifically screws with this pathway, they're called PARP inhibitors (see: https://www.cancer.org/cancer/prostate-cancer/treating/targeted-therapy.html). What these guys do is further inhibit the cell's ability to fix DNA, but only cells that have BRCA mutations (i.e. in this case the prostate cancer cells) will end up with so much damaged DNA they end up dying. Minimal side effects because your normal/non-cancer cells aren't severely hit by it .The problem, not all prostate cancer patients have BRCA mutations. So the search continues for these chess like opportunities and there's been plenty of breakthroughs over the years. https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies https://www.pennmedicine.org/cancer/navigating-cancer-care/treatment-types/immunotherapy/targeted-therapy https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/targeted-therapies

Glad you dodged that one Colin. No you shouldn't have to wait for symptoms. Sadly a lot of cancers still don't have adequate screening tests (e.g. pancreas, uterus, ovary...etc.). The two bright spots are cervical and breast cancer screening, and now we have a vaccine for cervical. Although with deferred screening because of the pandemic, we're expecting an uptick in late stage cancers. Not good. Lots of work still to be done. My thesis supervisor used to joke about it, and don't judge him too harshly he's a great and brilliant guy, he called it job security.

Therein lies the devil, it's in the details. "with additional risk". It was an accepted mitigator to reduce the number of false positives, although not enough of time has gone by to show if this was statistically correct. Remember PSA was introduced in the 90's (See below the jump in diagnosis when it was introduced, I was still a med student back then), and it took the better part of 3 decades of data to come to the current conclusion. It'll take just as long to see if adding a risk factor other than just age will improve the reliability of PSA and reduce the unnecessary morbidity of biopsies and treatment when neither would have been needed. Something you said above is especially pertinent. Most men die with prostate cancer than from it. Don't get me wrong, there's been plenty of advances in diagnostic techniques, it just takes decades of data, especially when we are taking about mortality rates ( so loooong follow up periods) for them to be validated. So expect another decade or more before we answer either question.

See explanation above Barry. You'll notice I talked about the zones, and specifically mentioned the symptoms of cancer arising in those zones not detected by a DRE. The urethral symptoms will give warning. Your link says the same thing but with less of medical explanation. Also, those cases of GP vs urologist, again see above when I said with proper training. I've had the misfortune of dealing with GPs who were as thick as a plank. A urologist would have proper training, one would hope. Just an FYI there is no such thing as a 100% accurate test. You take the best combination of sensitivity, specificity, positive and negative predictive values that you can get. For example, a PSA test was thought to be good enough until it turned out to be not sensitive enough (missing too many cases, i.e. false negatives), not specific enough (ejaculating, riding a bicycle, having a DRE or an infection are all things amongst a host of other non-cancer related things that can elevate your PSA, so massive over-diagnosis i.e. false positives), but good enough to follow a case post diagnosis/treatment after you have established a personalized baseline. You see a screening test needs to be sensitive enough to catch most cases (notice I said most, not all), without over-diagnosing cases that don't need to be treated or non-cancer cases. The PSA failed on both accounts. Currently, the DRE is the only thing that even comes close to fitting that description until studies on the newer diagnostic modalities provide statistical evidence. What you're quoting in that link sadly is medical legalese. They are covering their collective behinds as well as informing you, that a negative test does not mean you are cancer free, and if you read the whole thing, a positive test means we need to investigate further. It's the same warning on every single test. So if you do end up having cancer, "but the test was negative doc" "yeah, but we told you...". See where I'm going with this? This is my bread and butter specialty. I'm an MD/PhD in oncological sciences, researching and teaching this stuff for a couple of decades plus. If you're wondering my subspeciality is actually colon cancer, it's what I researched/wrote my thesis and published quite a bit on. Feel free to ask questions.

Decent prostate layman's guide from the NIH (American) https://www.cancer.gov/types/prostate/understanding-prostate-changes

You don't need to reach the whole prostate. The vast majority of prostate cancers originate in the peripheral zone (PZ in below image), that's what you can feel through the rectum. Also, with proper training it is anything but subjective. It's the difference between poking the muscle at the base of your thumb to poking your knuckle when it comes to hardness, rubbery vs hard. Not to mention smooth (normal) vs bumpy/craggy (not normal). That being said mutiparametric tests are being evaluated that include imaging (e.g.MRI) along with a cancer marker (blood) test. None have reached the numbers required for a solid conclusion. Now the reason we worry about PZ cancers is that they do not have early warning signs. Hence, the need to screen. While the other zones are wrapped closer around the urethra, they will announce themselves earlier with symptoms similar to benign prostate hyperplasia (hard to start a stream, hard to stop, dribbling...etc.). Bottom line, again pun not intended, don't ignore your DREs.

Yup nothing high tech about it yet unfortunately. 👆