I'd have rejected it on this one alone. I don't understand why people still smoke these days given how much is known about the health problems. Add to that the fact that you, your car, your house and your kids will smell...
I had the same problem finding a good example of an RX400h when I was looking. I guess cause of the type of car it's likely to have frequently been loaded up with kids, dogs, leisure equipment etc. Most of the ones I viewed at main dealers had quite a few scrapes inside and out. I ended up travelling to get mine.